Episode 273: Martha Carlin

by Brian Lenzkes, MD | Oct 29, 2025 | Podcast | 0 comments

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In this wide-ranging conversation, Dr. Brian Lenzkes welcomes microbiome researcher and entrepreneur Martha Carlin to explore how our inner ecosystem shapes metabolic, neurological, and emotional health. Martha’s journey began when her husband was diagnosed with Parkinson’s disease. Trained as an auditor, she followed the evidence—into food systems, antibiotic exposure, and ultimately the trillions of organisms that live in and on us.

Martha explains why the microbiome functions like an “internal pharmacy,” producing vitamins, hormones, and neurotransmitters that influence energy, mood, and resilience. She shares insights from stool sequencing work and discusses findings from a double-blind clinical trial of a targeted probiotic formula in people with metabolic issues, including reductions in serum endotoxin (LPS) and improvements in insulin-related markers over time—while noting that A1C changes are typically slower to appear.

The discussion gets practical. Brian and Martha cover the gut–brain axis and why chronic stress can shift microbial balance; the role of short-chain fatty acids; and why some people benefit from adding inulin or specific fibers. Martha offers a nuanced take on elimination diets, including carnivore approaches, and underscores the importance of “nose-to-tail” nutrition (e.g., collagen-rich cuts and hyaluronic acid) for maintaining the glycocalyx, the protective lining of the gut and vasculature. She also cautions against a one-size-fits-all use of microbes like Akkermansia, which can be context-dependent, and highlights research on Lactobacillus reuteri and oxytocin for social bonding and stress modulation.

Beyond food, Martha raises under-recognized environmental factors: surfactants found in common cleaning products may impact cellular membranes and immune balance, another reason to simplify inputs and support the body’s natural defenses. The episode closes with actionable themes—prioritize nutrient-dense foods, consider microbiome-supportive strategies (especially after antibiotics), manage stress intentionally, and personalize interventions rather than chasing fads.

Whether you’re curious about Parkinson’s and metabolism, coaching patients, or simply trying to feel and function better, this episode offers both big-picture frameworks and real-world tips to help you support the ecosystem within. As always: learn, experiment, and work with your clinician to tailor the plan to you.

For more information, please see the links below. Thank you for listening!

The Life’s Best Medicine Podcast is sponsored by HLTH Code.